HOME


HOME






NEWS


9th January 2019
Takashi Toda attended [広島大学 知のフォーラム in Tokyo] (Lecture Meeting by Nobel Laureate Sir Paul Nurse), which was held in Tokyo International Forum. In this event, he acted as a facilitator for Dr Paul Nurse.

Photos: top right and bottom left, President Dr Ochi (left) and Dr Paul Nurse (right); bottom right, Dr Takashi Toda (left), Dr Paul Nurse (middle) and Ms Kana Kubota (right, a presenter, a graduate from Hiroshima University).

 

 

 


9th January 2019
A new paper from Drs Toda and Yukawa group was published in G3: Genes, Genomes, Genetics.

Title:Suppressor analysis uncovers that MAPs and microtubule dynamics balance with the Cut7/Kinesin-5 motor for mitotic spindle assembly in Schizosaccharomyces pombe
Authors:Masashi Yukawa, Yusuke Yamada and Takashi Toda

January 1, 2019 vol. 9 no. 1 269-280; https://doi.org/10.1534/g3.118.200896


20th and 21st December 2018
Masashi Yukawa attended the expanded group meeting of Platform for Advanced Genome Science (PAGS) in Fukuoka and gave a poster presentation.

The title was:

Masashi Yukawa, Mitsuki Ohishi, Yusuke Yamada and Takashi Toda
Functional analysis of the RNA-binding protein Nrp1 in fission yeast
(分裂酵母の新規RNA結合タンパク質Nrp1の機能解析)


19th December 2018
Dr HIsanori Tamaki (Professor at Faculty of Agriculture, Kagoshima University) gave a talk as a speaker of the 36th HiHA seminar.

酵母が教えてくれること -細胞膜のメンテナンスから焼酎の酒質まで- (Lessons from yeast research-From plasma membrane integrity to Shochu(a traditional Japanese distilled spirit-)


13tn and 14th December 2018
The lab members and Dr Kazunori Kume went to Tsuneishi Shimanami Village (ツネイシしまなみビレッジ) for lab retreat.


7th December 2018
Dr Ryosuke Sato (Assistant Professor at Faculty of Pharmacology, Kindai University) gave a talk as a speaker of the 34th HiHA seminar.

The title of his talk was “MAPKシグナルが制御するRNA結合タンパク質 (The RNA-binding proteins regulated by MAPK signaling)”.


28th November 2018
Takashi Toda and Masashi Yukawa attended the 41st Annual meeting of the Molecular Biology Society of Japan (MBSJ) in Yokohama and gave their poster presentation.

 

The titles were

Takashi Toda, Yusuke Yamada, Tomoki Kawakami, Yasuhiro Teratani, Mitsuki Ohishi and Masashi Yukawa
Identification of multiple kinesin-dependent and independent pathways leading to bipolar spindle formation
(染色体分配に必須な紡錘体微小管構造を規定するキネシン依存的及び非依存的経路の同定)

Masashi Yukawa, Naoaki Kurisawa, Shakil Ahmed, Ken-ichi Kimura and Takashi Toda
A new screening approach for anti-tumor compounds using fission yeast
(分裂酵母を用いた抗がん剤シードとなる分子標的阻害物質の新規探索法)

Takashi Toda organised the evening forum session with Professors Masako Osumi and Susumu Kawamoto (President and advisor of NPO IIRS, 認定特定非営利活動法人 綜合画像研究支援). The speaker was Dr Kazuhiro Maeshima (Professor at the National Institute of Genetics). The title of his talk was “細胞の中のクロマチンの動きを見る” (Visualization of dynamic chromatin in the cell).

Photo from the left, Masako Osumi, Susumu Kawamoto, Kazuhiro Maeshima and Takashi Toda


21st November 2018
A new paper was accepted in G3 and published online.

URL: http://www.g3journal.org/content/early/2018/11/21/g3.118.200896 (G3)
https://www.ncbi.nlm.nih.gov/pubmed/30463883 (PubMed)

Title:Suppressor analysis uncovers that MAPs and microtubule dynamics balance with the Cut7/Kinesin-5 motor for mitotic spindle assembly in Schizosaccharomyces pombe
Authors:Masashi Yukawa, Yusuke Yamada and Takashi Toda
Journal:G3


3th November 2018
4 lab members (Takashi Toda, Masashi Yukawa, Ryo Moriyama, Satoshi Muto) attended 36th Yeast Workshop held at Ehime University.
Masashi presented an overview of our research and Ryo and Satoshi gave both oral and poster presentations.


The titles were

Rio Moriyama
分裂酵母を利用した新規生理活性物質の探索と解析
Screening and characterisation of new anti-fungal compounds using fission yeast

Satoshi Muto
分裂酵母5型キネシンcut7変異を抑圧する多コピーサプレッサーの取得と解析
Isolation and characterisation of multi-copy suppressors of cut7 mutants defective in fission yeast Kinesin-5


11th and 12th October 2018
Takashi Toda attended MIRAI Seminar “Sustainable Social System and Technology for Ageing Society)” held at Wasoeda University. This event was organised by researchers belonging to several universities in Japan (Hiroshima University is one of them) and Sweden by which to aim to promote international collaborations between these two nations. Takashi presented an oral talk. His title was “Towards achieving healthy ageing society-from basic biology to applied science”.

The photo was taken with Dr Masayuki Kakehashi (Professor at Hiroshima University).


10th October 2018
10th HiHA International Workshop “Towards an understanding of chromosome dynamics, segregation and function” was held in Hiroshima University (organised by Dr Masaru Ueno). Takashi Toda gave an oral presentation. The title of his talk was “Motor-dependent and -independent pathways leading to bipolar spindle assembly”. A special guest speaker from the United States was Dr Julie Cooper (center in the group photo, Professor at the National Institute of Health), who used to work in London Research Institute, Cancer Research UK when Takashi also had a lab there.


28th September 2018
Takashi Toda, Masashi Yukawa, Satoshi Muto and Ryo Moriyama attended 21st Exchange Meeting on Microeukaryotes held at The National Research Institute of Brewing (NRIB). The photo was taken in a social gathering party after the meeting.


21st September 2018

Nick Rhind (Professor at University of Massachusetts Medical School, USA) gave an informal talk in our department (host: Masaru Ueno).
The title of his talk was “Regulation of Replication Timing(DNA複製タイミングの制御)”


12th-13th September 2018

Takashi Toda attended 22nd Yeast Joint Symposium held in Kyushu University and gave a plenary lecture.
The title of his talk was “How mitotic spindles assemble-from basic biology to application” (スピンドル微小管はいかに形成されるのかー基礎から応用まで).


10th-12th September 2018

6 lab members (Takashi Toda, Masashi Yukawa, Yusuke Yamada, Tomoki Kawakami, Mitsuki Ohishi and Yasuhiro Teratani) attended 51st annual meeting of Yeast Genetic Society of Japan held in Kyushu University and presented their works.

Oral talk

Takashi Toda: Exploring specific inhibitors against human Kinesin-14 using fission yeast (分裂酵母を用いたヒト14型キネシン阻害剤の探索)

Masashi Yukawa: Identification of molecular pathways leading to mitotic bipolar spindle formation (M期紡錘体の双極性構造形成に働く分子経路の探索)

Tomoki Kawakami:A novel role of the Alp7-Alp14 microtubule polymerase as a force generator in bipolar spindle formation (双極性紡錘体形成における力発生装置としての微小管ポリメラーゼ複合体Alp7-Alp14の新規機能)

Yusuke Yamada: Identification and characterisation of microtubule associated proteins that antagonise Kinesin-5/Cut7 in fission yeast (分裂酵母Kinesin-5/Cut7と拮抗的に機能する微小管関連因子群の同定と解析)

 

Poster presentation:

Yasuhiro Teratani: Systematic identification and analysis of cut7 mutations isolated with PCR-based mutagenesis (PCR法を用いた分裂酵母5型キネシンcut7変異体の包括的分離と解析)

Mitsuki Ohishi: Analysis of an RNA binding protein Nrp1 that, when mutated, suppresses the lethal cut7 mutation (M期紡錘体形成に必須な分裂酵母5型キネシンcut7変異を抑制するRNA結合タンパク質遺伝子nrp1の解析)


31st August 2018

Takashi Toda gave a talk in the 1st HiHA-HIRAKU workshop. The title was “Message to young researchers”.

 

日本語


24th July 2018

Takashi Toda visited National Institute of Genetics in Mishima to attend viva of Koki Watanabe as an external examiner. Koki Watanabe is a PhD student of Daijyu Kitagawa (currently, Professor at Graduate School of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, the University of Tokyo).

Photo: from the left, Toyoaki Netsume, Takashi Toda, Daijyu Kitagawa, Masato Kanemaki


21st June 2018

Dr Takayuki Koyano gave a talk in 30th HiHA seminar. The title was “腎臓病の病態解明に向けた分子遺伝学的解析―ゲノム編集技術を利用したモデル動物作製から解析まで―”.

Dr Koyano graduated from Department of Molecular Biotechnology Graduate School of Advanced Sciences of Matter, Hiroshima University and obtained PhD. After that, he joined Takashi Toda’s laboratory at the Francis Crick Institute and spent for two years in London (2013-2015). Then he got a research scientist job in Shigei Medical Research Institute (重井医学研究所) in Okayama, Japan.


13th June 2018
Takashi Toda and Masashi Yukawa visited Professor Wataru Yasui (安井 弥教授, on the left in the photo) and Associate Professor Naohide Oue (大上直秀准教授, on the right) in Department of Molecular Pathology, Institute of Biomedical & Health Science, Hiroshima University, and discussed potential collaborative research on human kinesin molecules and their inhibitors. Professor Yasui’s group has found that several kinesin genes including KifC1/HSET are specifically upregulated in many cancer stem cells including gastric, oesophageal and colorectal cancers. They have further shown that knockdown of these kinesin genes kill various cancer cells. Takashi Toda’s group has been working on kinesins in fission yeast and recently shown that KifC1/HSET is functional in fission yeast. Furthermore, they have been developing novel inhibitors specific to human kinesin.


6th and 7th Jun 2018
Takashi Toda attended Joint Annual Meeting of 51st JSDB (Japanese Society of Developmental Biology) and 70th JSCB (Japan Society for Cell Biology) held in Tokyo, and gave an oral talk and also did a poster presentation.


Title

Exploring the molecular pathways leading to bipolar spindle formation


Authors

Takashi Toda, Masaki Okazaki, Tomoaki Yamauchi, Yusuke Yamada, Tomoki Kawakami, Yasuhiro Teratani, Mitsuki Oishi and Masashi Yukawa

The photo was taken in front of the poster. Masazumi Tada came from UK. He is Lecturer at the department of Cell and Developmental Biology in University College London. Masazumi is a developmental biologist working on zebrafish and Takashi’s good friend as well. Takashi collaborated with him on the Msd1 project and published one joint paper in EMBO Reports in 2014.