14th April

Annual get-gather party for regional yeast researchers was held on 14th April at National Research Institute of Brewing within the science park in HIgashi-Hiroshima. This year the party was organised by Professor Akinori Matsushika at National Institute of Advanced Industrial Science(AIST). Approximately 60 yeast researchers working in the HIgashi-Hiroshima area attended. From our group, five members (Takashi Toda, Masashi Yukawa, Mitsuki Ohishi, Ryo Murayama and Satoshi Muto) attended and enjoyed talking to attendants and drinking sake.

9th April

A new paper was published from Takashi Toda and Masashi Yukawa group. This work was achieved through international collaborations performed by three research teams in Hiroshima University (Toda and Yukawa), Iwate University (Ken-ichi Kimura) and CSIR-Central Drug Research Institute in India (Shakil Ahmed). The research was in part supported by a JSPS grant “Fostering international researchers through the collaborative research network focusing on the mechanisms of lifespan regulation ”.

Authors: Masashi Yukawa, Tomoaki Yamauchi, Naoaki Kurisawa, Shakil Ahmed, Ken-ichi Kimura, and Takashi Toda
Titile: Fission yeast cells overproducing HSET/KIFC1 provides a useful tool for identification and evaluation of human kinesin-14 inhibitors
Journal: Fungal Genetics and Biology, in press
Doi: https://doi.org/10.1016/j.fgb.2018.04.006

1st April

Undergraduate students, Satoshi Muto (武藤 慧) and Ryo Moriyama (森山 亮) joined the lab.

23th March

The second year graduate school students, Masaki Okazaki and Tomoaki Yamauchi, have completed the academic degree (Master degree) and graduated from Hiroshima University (photo).
Many congratulations. Masaki and Tomoaki worked very hard, performed wonderful jobs and made great achievements while they were with us.
Farewell to both of them and good luck with new places.

The fourth year undergraduate students, Mitsuki Ohishi and Yasuhiro Teratani, have finished the undergaraduate course and will be enrolled into the graduate programmes from April.

15th-17th March
Masashi Yukawa attended the 2018 annual meeting of the JSBBA held in Nagoya and had an oral presentation.
Masashi Yukawa, Yusuke Yamada, Tomoaki Yamauchi and Takashi Toda
The role of kinesin-14 family proteins in bipolar spindle assembly

湯川格史, 山田侑亮, 山内智瑛, 登田 隆

13th and 14th March
Takashi Toda attended the 10th HOPE meeting held in Yokohama, Japan. HOPE Meetings have been organized by the Japan Society for the Promotion of Science (JSPS) since 2008. The title “HOPE” signifies the promise held for young scientists and optimism for a bright science and technology future in the Asia-Pacific and Africa region. Eight Nobel Prize laureates from both Japan and overseas gathered this year together with ~100 young researchers from over 20 countries.

Takashi was the moderator for Dr Tim Hunt. Sir Tim was awarded the Nobel Prize in Physiology or Medicine with Leland Hartwell and Paul Nurse for his discovery of the ‘disappearing’ molecule called Cyclin, a “key regulator of the cell cycle”. Takashi know Dr Tim Hunt very well, as they used to work in London Research Institute of Cancer Research UK (now the Francis Crick Institute), collaborate and publish joint papers.

12th March 2018
5th HiHA International Symposium was held.
This symposium was registered as an Inter-Graduate School Educational Seminar for students who belong to 5 Graduate Schools.

Building of Graduate School of Advanced Sciences of Matter, 4F ROOM 401N


Please see the poster

17th February 2018

A new paper on which Dr Corinne Pinder (a research scientist in Dr Takashi Toda group) is a co-author, was published.
The paper ‘LARP7 family proteins have conserved function in telomerase assembly’ appeared in Nature Communications online.
Dr Corinne Pinder was supported by a JSPS grant “Program for Advancing Strategic International Networks to Accelerate the Circulation of Talented Researchers”-funded 『Fostering international researchers through the collaborative research network focusing on the mechanisms of lifespan regulation』.

This work was performed in Dr Kazu Tomita group (University College London, London UK) under collaboration with groups in both London, UK (UCL and Imperial College) and Massachusetts, USA (Salem State University.
The work addresses the important question of telomerase regulation, a crucial enzyme in ageing and cancer, and differences in telomerase biogenesis between species. Specifically, fission yeast Lar7 is a conserved RNA-binding protein that protects telomerase RNA from degradation. Lar7 also stabilises the formation of the mature telomerase complex for its localisation to the telomere for stable genome propagation and healthy ageing.
Dr Corinne Pinder was currently supported by JSPS grant『Fostering international researchers through the collaborative research network focusing on the mechanisms of lifespan regulation』. Dr Kazu Tomita received PhD in Shizuoka University in the laboratory of Dr Masaru Ueno (currently a core member of HiHA).

Collopy LC, Ware TL, Goncalves T, S IK, Yang Q, Amelina H, Pinder C, Alenazi A, Moiseeva V, Pearson SR, Armstrong CA, Tomita K (2018). LARP7 family proteins have conserved function in telomerase assembly. Nat Commun 9, 557.

5th February 2018

A new manuscript from Takashi Toda group (collaboration with Dr Ken-ichi Kimora, Iwate University) was deposited to bioRxiv online.

Fission yeast cells overproducing HSET/KIFC1 provides a useful tool for identification and evaluation of human kinesin-14 inhibitors
Masashi Yukawa, Tomoaki Yamauchi, Ken-ichi Kimura and Takashi Toda


7th February 2018

Takashi Toda gave a talk at the National Institute of Basic Biology in Okazaki.
The title of the talk was “極東酵母の微小管日記 (Microtubule diary from far (y)east)”.


Taken with Dr Yoshiaki Kamata (left, Assistant Professor) and Dr Akira Yakashita (right, Associate Professor) at the Maruya Hatcho Miso factory (まるや、八丁味噌工場).

Taken with Dr Masayuki Yamamoto (the third from the right, Director of the NIBB) and Dr Tomomi Tsubouchi (the third from the left, a host, Associate Professor) at HASEBE, eel (うなぎ) restaurant..


Takashi Toda and Masashi Yukawa wrote a short review article in Experimental Medicine in Japanese (実験医学).

Title: タンパク質脱リン酸酵素の“えこ贔屓”:2A型ホスファターゼPP2A-B55はセリンよりスレオニンがお好き
(Favouritism of protein phosphatase: type 2A phosphatase-B55 prefers threonine to serine)

Experimental Medicine (実験医学)(2018) 36:No. 3, 402-404.

5th January 2018

Corinne Pinder (品田子鈴) joined the lab from the Francis Crick Institute as a research scientist.