3th November 2018
4 lab members (Takashi Toda, Masashi Yukawa, Ryo Moriyama, Satoshi Muto) attended 36th Yeast Workshop held at Ehime University.
Masashi presented an overview of our research and Ryo and Satoshi gave both oral and poster presentations.

The titles were

Rio Moriyama
Screening and characterisation of new anti-fungal compounds using fission yeast

Satoshi Muto
Isolation and characterisation of multi-copy suppressors of cut7 mutants defective in fission yeast Kinesin-5

11th and 12th October 2018
Takashi Toda attended MIRAI Seminar “Sustainable Social System and Technology for Ageing Society)” held at Wasoeda University. This event was organised by researchers belonging to several universities in Japan (Hiroshima University is one of them) and Sweden by which to aim to promote international collaborations between these two nations. Takashi presented an oral talk. His title was “Towards achieving healthy ageing society-from basic biology to applied science”.

The photo was taken with Dr Masayuki Kakehashi (Professor at Hiroshima University).

10th October 2018
10th HiHA International Workshop “Towards an understanding of chromosome dynamics, segregation and function” was held in Hiroshima University (organised by Dr Masaru Ueno). Takashi Toda gave an oral presentation. The title of his talk was “Motor-dependent and -independent pathways leading to bipolar spindle assembly”. A special guest speaker from the United States was Dr Julie Cooper (center in the group photo, Professor at the National Institute of Health), who used to work in London Research Institute, Cancer Research UK when Takashi also had a lab there.

28th September 2018
Takashi Toda, Masashi Yukawa, Satoshi Muto and Ryo Moriyama attended 21st Exchange Meeting on Microeukaryotes held at The National Research Institute of Brewing (NRIB). The photo was taken in a social gathering party after the meeting.

21st September 2018

Nick Rhind (Professor at University of Massachusetts Medical School, USA) gave an informal talk in our department (host: Masaru Ueno).
The title of his talk was “Regulation of Replication Timing(DNA複製タイミングの制御)”

12th-13th September 2018

Takashi Toda attended 22nd Yeast Joint Symposium held in Kyushu University and gave a plenary lecture.
The title of his talk was “How mitotic spindles assemble-from basic biology to application” (スピンドル微小管はいかに形成されるのかー基礎から応用まで).

10th-12th September 2018

6 lab members (Takashi Toda, Masashi Yukawa, Yusuke Yamada, Tomoki Kawakami, Mitsuki Ohishi and Yasuhiro Teratani) attended 51st annual meeting of Yeast Genetic Society of Japan held in Kyushu University and presented their works.

Oral talk

Takashi Toda: Exploring specific inhibitors against human Kinesin-14 using fission yeast (分裂酵母を用いたヒト14型キネシン阻害剤の探索)

Masashi Yukawa: Identification of molecular pathways leading to mitotic bipolar spindle formation (M期紡錘体の双極性構造形成に働く分子経路の探索)

Tomoki Kawakami:A novel role of the Alp7-Alp14 microtubule polymerase as a force generator in bipolar spindle formation (双極性紡錘体形成における力発生装置としての微小管ポリメラーゼ複合体Alp7-Alp14の新規機能)

Yusuke Yamada: Identification and characterisation of microtubule associated proteins that antagonise Kinesin-5/Cut7 in fission yeast (分裂酵母Kinesin-5/Cut7と拮抗的に機能する微小管関連因子群の同定と解析)


Poster presentation:

Yasuhiro Teratani: Systematic identification and analysis of cut7 mutations isolated with PCR-based mutagenesis (PCR法を用いた分裂酵母5型キネシンcut7変異体の包括的分離と解析)

Mitsuki Ohishi: Analysis of an RNA binding protein Nrp1 that, when mutated, suppresses the lethal cut7 mutation (M期紡錘体形成に必須な分裂酵母5型キネシンcut7変異を抑制するRNA結合タンパク質遺伝子nrp1の解析)

31st August 2018

Takashi Toda gave a talk in the 1st HiHA-HIRAKU workshop. The title was “Message to young researchers”.



24th July 2018

Takashi Toda visited National Institute of Genetics in Mishima to attend viva of Koki Watanabe as an external examiner. Koki Watanabe is a PhD student of Daijyu Kitagawa (currently, Professor at Graduate School of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, the University of Tokyo).

Photo: from the left, Toyoaki Netsume, Takashi Toda, Daijyu Kitagawa, Masato Kanemaki

21st June 2018

Dr Takayuki Koyano gave a talk in 30th HiHA seminar. The title was “腎臓病の病態解明に向けた分子遺伝学的解析―ゲノム編集技術を利用したモデル動物作製から解析まで―”.

Dr Koyano graduated from Department of Molecular Biotechnology Graduate School of Advanced Sciences of Matter, Hiroshima University and obtained PhD. After that, he joined Takashi Toda’s laboratory at the Francis Crick Institute and spent for two years in London (2013-2015). Then he got a research scientist job in Shigei Medical Research Institute (重井医学研究所) in Okayama, Japan.

13th June 2018
Takashi Toda and Masashi Yukawa visited Professor Wataru Yasui (安井 弥教授, on the left in the photo) and Associate Professor Naohide Oue (大上直秀准教授, on the right) in Department of Molecular Pathology, Institute of Biomedical & Health Science, Hiroshima University, and discussed potential collaborative research on human kinesin molecules and their inhibitors. Professor Yasui’s group has found that several kinesin genes including KifC1/HSET are specifically upregulated in many cancer stem cells including gastric, oesophageal and colorectal cancers. They have further shown that knockdown of these kinesin genes kill various cancer cells. Takashi Toda’s group has been working on kinesins in fission yeast and recently shown that KifC1/HSET is functional in fission yeast. Furthermore, they have been developing novel inhibitors specific to human kinesin.

6th and 7th Jun 2018
Takashi Toda attended Joint Annual Meeting of 51st JSDB (Japanese Society of Developmental Biology) and 70th JSCB (Japan Society for Cell Biology) held in Tokyo, and gave an oral talk and also did a poster presentation.


Exploring the molecular pathways leading to bipolar spindle formation


Takashi Toda, Masaki Okazaki, Tomoaki Yamauchi, Yusuke Yamada, Tomoki Kawakami, Yasuhiro Teratani, Mitsuki Oishi and Masashi Yukawa

The photo was taken in front of the poster. Masazumi Tada came from UK. He is Lecturer at the department of Cell and Developmental Biology in University College London. Masazumi is a developmental biologist working on zebrafish and Takashi’s good friend as well. Takashi collaborated with him on the Msd1 project and published one joint paper in EMBO Reports in 2014.

29th May 2018

Vismaya Kharkar joined the lab as a summer student. Vismaya is a second year undergraduate student from Harvard University. Hiroshima University is hosting 6 students from Harvard University this year and Vismaya is one of them. She will stay in the lab for 10 weeks and be engaged with a research project. The photo was taken with her farther and the lab members.

16th May 2018

President Michio Ochi of Hiroshima University invited Nobel Laureate, Professor Yoshinori Ohsumi (2016 Nobel Prize for Medicine or Physiology,Tokyo Institute of Technology) as a special lecturer for an opening event of new faculties, School of Informatics and Data Science and Department of Integrated Global Studies (情報科学部と総合科学部国際共創学科).

The event was held in Hiroshima Grand Prince Hotel. It consisted of a lecture by Professor Ohsumi, followed by a celebration party for these newly established faculties. Takashi Toda and Masashi Yukawa attended this event.

15th May 2018

After staying for more than 4 months in our laboratory, Corinne Pinder has completed postdoctoral work and returned to UK. Thank you very much. We wish Corinne the best of luck.

20th April

Takashi Toda attended the 21st board meeting of Japan Microbiology Association held at the Science Council of Japan in Tokyo. The reason for this attendance was to establish and strength the domestic research network between the HiHA and microbiologists/medical researchers to promote collaborative programmes.


14th April

Annual get-gather party for regional yeast researchers was held on 14th April at National Research Institute of Brewing within the science park in HIgashi-Hiroshima. This year the party was organised by Professor Akinori Matsushika at National Institute of Advanced Industrial Science(AIST). Approximately 60 yeast researchers working in the HIgashi-Hiroshima area attended. From our group, five members (Takashi Toda, Masashi Yukawa, Mitsuki Ohishi, Ryo Murayama and Satoshi Muto) attended and enjoyed talking to attendants and drinking sake.

9th April

A new paper was published from Takashi Toda and Masashi Yukawa group. This work was achieved through international collaborations performed by three research teams in Hiroshima University (Toda and Yukawa), Iwate University (Ken-ichi Kimura) and CSIR-Central Drug Research Institute in India (Shakil Ahmed). The research was in part supported by a JSPS grant “Fostering international researchers through the collaborative research network focusing on the mechanisms of lifespan regulation ”.

Authors: Masashi Yukawa, Tomoaki Yamauchi, Naoaki Kurisawa, Shakil Ahmed, Ken-ichi Kimura, and Takashi Toda
Titile: Fission yeast cells overproducing HSET/KIFC1 provides a useful tool for identification and evaluation of human kinesin-14 inhibitors
Journal: Fungal Genetics and Biology Volume 116, July 2018, Pages 33–41 Abstract

1st April

Undergraduate students, Satoshi Muto (武藤 慧) and Ryo Moriyama (森山 亮) joined the lab.