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19th June 2021
Takashi Toda received the 2nd shot of the Pfizer COVID-19 vaccine.


9th June 2021
Takashi Toda hosted the 66th HiHA Seminar/Webinar by Dr Toru Hirota, Chief scientist at Cancer Institute of the Japanese Foundation for Cancer Research.

Speaker: Dr Toru Hirota(広田 享部長、公益法人がん研究会がん研究所 実験病理部)

Title: 染色体の安定性を保証する染色体分離の時空間的制御特性とその分子機構の解明 (Elucidation of the spatiotemporal regulation and the mechanism of chromosome separation that ensures chromosome stability)

This seminar was performed via internet (Webinar).


29th May 2021
Takashi Toda received the 1st shot of the Pfizer COVID-19 vaccine. It went well without any adverse reactions except some pain in the arm where the vaccine was injected. The second jab will be scheduled three weeks time.


19th May 2021
Takashi Toda hosted the 65th HiHA Seminar/Webinar by Dr Kazuhide Asakawa, Associate Professor at Tokyo Medical University and National Institute of Genetics.

Speaker: Dr Kazuhide Asakawa(浅川和秀准教授)

Title: 光遺伝学でALSの謎に迫る (Investigating the mystery of ALS using optogenetics)

This seminar was performed via internet (Webinar).


12th May 2021
Takashi Toda hosted the 64th HiHA Seminar/Webinar by Dr Kozo Tanaka, Professor at Institute of Development, Ageing and Cancer, Tohoku University.

Speaker: Prof Kozo Tanaka(田中耕三教授)

Title: 染色体オシレーションによる染色体安定性維持機構 (Mechanisms of Chromosome Stability through Chromosome Oscillation)

This seminar was performed via internet (Webinar).


30th April 2021
A new paper was published in International Journal of Molecular Sciences.

Authors: Masashi Yukawa, Mitsuki Ohishi, Yusuke Yamada and Takashi Toda

Title: The Putative RNA-Binding Protein Dri1 Promotes the Loading of Kinesin-14/Klp2 to the Mitotic Spindle and Is Sequestered into Heat-Induced Protein Aggregates in Fission Yeast.

Journal: International Journal of Molecular Sciences 2021; 22(9):4795
URL: https://www.mdpi.com/1422-0067/22/9/4795
DOI: 10.3390/ijms22094795


21st April 2021
Takashi Toda hosted the 63rd HiHA Seminar/Webinar by Dr Fumio Motegi, Professor at Institute for Genetic Medicine, Hokkaido University.

Speaker: Fumio Motegi(茂木文夫教授)

Title: 受精卵の非対称パターン化を脱構築と再構築で理解する (Understanding the mechanism underlying the asymmetrical patternization of fertilized eggs from a view point of deconstruction and reconstruction)

This seminar was performed via internet (Webinar).


5th April 2021
A new paper was published in Pathology International. This work was performed under collaboration with laboratories of Prof Wataru Yasui, Prof Naohide Oue and Prof Hideki Ohdan (Graduate School of Biomedical and Health Sciences, Hiroshima University) and Ken-ichi Kimura (Department of Agriculture, Iwate University).

Authors: Shintaro Akabane, Naohide Oue, Yohei Sekino, Ryuichi Asai, Pham Quoc Thang, Daiki Taniyama, Kazuhiro Sentani, Masashi Yukawa, Takashi Toda, Ken‐ichi Kimura, Hiroyuki Egi, Wataru Shimizu, Hideki Ohdan and Wataru Yasui

Title:KIFC1 regulates ZWINT to promote tumor progression and spheroid formation in colorectal cancer

Journal:Pathology International 2021; 71
URL: https://onlinelibrary.wiley.com/doi/10.1111/pin.13098
DOI: 10.1111/pin.13098


1st April 2021
New members joined the lab.

B4: Jae Uk Hwang and Masahiro Kawasumi
M1: Sharmin Sultana (Because of the Covid-19 pandemic, Sharmin stays in Bangladesh and attend classes and lab activities on-line until she can receive visa and enter Japan)
Woo Sang Hwang is enrolled in a graduate school (M1).

The photo shows our first lab meeting performed on-line.


23rd March 2021
The fourth year undergraduate students, Woo Sang Hwang and Kojiro Matsuo, have finished the undergaraduate course.
Woo Sang Hwang will be enrolled in our graduate program from April.


20th March 2021
Masashi Yukawa attended the 2021 annual meeting of the JSBBA held in Sendai and had an oral presentation (Online).

Masashi Yukawa and Takashi Toda
Actin-dependent nuclear displacement leads to escape from mitotic catastrophe in fission yeast

湯川格史, 登田 隆
アクチン依存的な核移動による分裂酵母M期カタストロフからの回避機構


19th March 2021
Takashi Toda attended 1st HIRAKU-Global International Symposium as a panelist. He serves HIRAKU Global as an advisory board member.

This symposium was held on-line.


4th March 2021
Takashi Toda hosted the 62nd HiHA Seminar/Webinar by Dr Hitoshi Nakatogawa, Associate Professor at Integrated Research Institute, Tokyo Technology of University.

Speaker: Speaker: Hitoshi Nakatogawa(中戸川 仁准教授)

Title: オートファジーによるオルガネラ分解のメカニズム (Mechanism of organella degradation by authophagy)

This seminar was performed via internet (Webinar).


19th February 2021
Takashi Toda and Masashi Yukawa wrote a mini-review in March Issue of Experimental Medicine (実験医学).

Title: Dual regulation of the MAP kinase by heat shock chaperones(熱ショックシャペロンによるMAPキナーゼ経路の二面的制御)

URL: https://www.yodosha.co.jp/jikkenigaku/book/9784758125413/


16th February 2021
4th year undergraduate students, Kojiro Matsuo and Woo Sang Hwang, presented their graduation researches.

Kojiro Matsuo
“分裂酵母を用いたヒト癌関連遺伝子発現系の開発”
(Development of advanced system to overexpress human cancer-related genes in fission yeast cells)

Woo Sang Hwang
“M期紡錘体形成に必須な5型キネシンモーターの機能解析”
(Functional analysis of Kinesin-5 motors required for assembly of the mitotic spindle)


12th February 2021
Takashi Toda hosted the 61st HiHA Seminar/Webinar by Dr Ryotaro Nishi, Associate Professor at Department of Bioscience and Biotechnology, Tokyo University of Technology.

Speaker: Ryotaro Nishi(西良太郎准教授)

Title: 核スペックルを介したDNA二本鎖切断の修復機構 (The repair mechanism of DNA double starnd break thorugh the nuclear speckle)

This seminar was performed via internet (Webinar).


22nd January 2021
Takashi Toda hosted the 59th HiHA Seminar/Webinar by Professor Daiju Kitagawa at Graduate School of Pharmaceutical Sciences, University of Tokyo.

Speaker: Professor Daiju Kitagawa (北川大樹教授)

Title: ヒト細胞における中心体複製機構と遺伝性疾患 (Mechanisms of centriole duplication in human cells and genetic disorders)

This seminar was performed via internet (Webinar).


21st January 2021
A new paper was published in iScience.

Authors: Masashi Yukawa, Yasuhiro Teratani and Takashi Toda.

Title: Escape from mitotic catastrophe by actin-dependent nuclear displacement in fission yeast.

Journal: iSciences 2021; 24(1):102031
URL: https://www.cell.com/iscience/fulltext/S2589-0042(20)31228-1
DOI: 10.1016/j.isci.2020.102031

This work was featured in Hiroshima University HP at https://www.hiroshima-u.ac.jp/ilife/news/62954 and https://www.hiroshima-u.ac.jp/en/news/62877, and also in the following three international URL sites (Eurekalert! at https://www.eurekalert.org/pub_releases/2021-02/hu-ri020321.php, Asia Research News at https://www.asiaresearchnews.com/content/researchers-identify-%E2%80%9Crescue%E2%80%9D-mechanism-helps-cells-survive-malfunctioning-split and Alpha Galileo at https://www.alphagalileo.org/en-gb/Item-Display/ItemId/204151).


3rd December 2020
Takashi Toda performed a poster presentation in the 43rd annual meeting of the Molecular Biology Society of Japan.

The authros: Takashi Toda and Masashi Yukawa

The title: 「分裂酵母M期カタストロフ/cutはアクチン依存的な細胞核移動により回避される」 (Actin-dependent nuclear displacement leads to escape from mitotic catastrophe/cut in fission yeast)

This seminar was performed via internet (Webinar).


2nd December 2020
Takashi Toda hosted the lecture by Dr Akihiko Nakano in the forum session of the 43rd annual meeting of the Molecular Biology Society of Japan.

The speaker: Dr Akihiko Nakano

Affiliations: Riken Center for Advanced Photonics, Team Leader and Vice Director

The title:「細胞内膜交通の超⾼時空間分解能ライブイメージング」 (Live imaging of intracellular membrane traffic at ultrahigh-spatiotemporal resolution)

This seminar was cosponsored by NPO, IIRS (認定特定⾮営利活動法⼈ 綜合画像研究⽀援)and performed via internet (Webinar).

Photo: left (Akihiko Nakano, speaker); right (Susumu Kawamoto, co-host)


24th November 2020
Takashi Toda hosted the 57th HIHA Seminar/Webinar by Dr Masato Kanemaki, Professorr at National Institue of Genetics, Mishima (国立遺伝学研究所).

The title: 「AID2は細胞及びマウス個体においてシャープなタンパク質分解制御を可能にする」 (AID2 enables regulatable sharp protein desctruction both in culturted cells and inside mice bodies)

This seminar was performed via internet (Webinar).


13th October 2020
Takashi Toda hosted the 55th HIHA Seminar/Webinar by Dr Tomomi Kiyomitsu, Associate Professor at Okinawa Institute of Science and Technology Graduate University (OIST, 沖縄科学技術大学院大学).

The title: 「急速タンパク分解で見えてきたRan依存的な紡錘体形成の仕組み」 (Mechanims of Ran-dependent mitotic spindle formation revealed by a rapid protein degradation system)

This seminar was performed via internet (Webinar).


6th October 2020
Takashi Toda hosted the 54th HIHA Seminar/Webinar by Dr Tomoya Kitajima, Team Leader at RIKEN Center for Biosystems Dynamics Research, Kobe (BDR, 理化学研究所・生命機能科学研究センター).

The title: 「卵子における染色体分配」 (Mechanims of chromosome segregation in mammmalian oocytes)

This seminar was performed via internet (Webinar).


7th-9th September 2020
Takashi Toda and Masashi Yukawa attended 53rd annual meeting of Yeast Genetic Society of Japan (Online) and presented their works.

Oral talk

Takashi Toda: Escape from mitotic catastrophe by actin-dependent nuclear displacement in fission yeast
(アクチン依存的な核移動による分裂酵母M期カタストロフからの回避機構)

Masashi Yukawa: Functional analysis of the fission yeast RNA-binding proteins in bipolar spindle formation
(分裂酵母新規RNA結合タンパク質の紡錘体形成における機能解析)


28th August 2020
Takashi Toda hosted the 52nd HIHA Seminar/Webinar by Dr Yuu Kimata, Associate Professor at Shanghi Tech University, China.

The title: 「多細胞生物の細胞周期制御因子による細胞分化協調メカニズム」 (Coodination mechanisms of cell differenciation by cell cycle regulatory factors in multicellular organisms)

This seminar was performed via internet (Webinar).


21st July 2020
Masashi Yukawa hosted the 50th HIHA seminar by Dr Haruhiko Asakawa, Associate Professor at Osaka Unviersity,

The title: 核膜孔複合体: 分裂酵母に見られる特異的構造とその意義 (The Nuclear Pore Complex: Specific structure and its significance in the fission yeast)

This seminar was performed via internet (Webinar).


3rd July 2020
Takashi Toda hosted the 49th HIHA seminar by Dr Ryota Uehara, Associate Professor at Hokkaido University,

The title: 動物体細胞はなぜ二倍体でないといけないのか (Why do anima cells maintain diploidy?)

This seminar was performed via internet (Webinar).


15th June 2020
Ms Ohshita joined our group as a technical staff.


7th May 2020
A new paper from Drs Toda and Yukawa group was published in Cells online.

Authors: Masashi Yukawa, Yasuhiro Teratani and Takashi Toda
Titile: How essential Kinesin-5 becomes non-essential in fission yeast: force balance and microtubule dynamics matter

Journal: Cells (2020 ; 9(5): E1154)
URL: Cells /PubMed
DOI: 10.3390/cells9051154


1st April 2020
New B4 students, Kojiro Matsuo (松尾光治良、left) and Woo Sang Hwang (right) joined our group.


23rd March 2020
Master course students, Mitsuki Ohishi and Yasuhiro Teratani, successfully completed their courses and graduated from the university. Many congratulations. Well done, both of you.
Good luck in your new jobs and places.


24th February 2020
Takashi Toda visited the Francis Crick Institute and discussed research collaboration with Sir Paul Nurse (Director and CEO of the institute).

2020年2月24日
登田 隆教授が英国フランシス・クリック研究所を訪問し、研究所長のSir ポール・ナース博士と、国際共同研究について打ち合わせ会議をもちました。


18th February 2020
2nd year graduate students, Mitsuki Ohishi and Yasuhiro Teratani, presented their master course researches.

Mitsuki Ohish
“分裂酵母新規RNA結合タンパク質Nrp1の機能解析”
(Exploring the roles for a novel RNA binding protein Nrp1 in fission yeast)

Yasuhiro Teratani
“分裂酵母5型キネシンCut7の細胞周期M期における新規機能”
(Novel roles of fission yeast Kinesin-5 Cut7 in M phase)


13th February 2020
4th year undergraduate students, Tomoro Kaku and Tomoharu Tanaka, presented their graduation researches.

Tomoro Kaku
“分裂酵母RNA結合タンパク質Rct1の紡錘体微小管形成における機能解析”
(Characterisation of the roles for RNA binding protein Rct1 in bipolar spindle assembly in fission yeast)

Tomoharu Tanaka
“分裂酵母を利用した植物共生放線菌からの新規生理活性物質の探索”
(Search for biologically active substances from plant symbiotic actinomycetes using fission yeast)


28th January 2020
Takashi Toda talked with Dr Takaaki Hirotsu and attended his seminar held in School of Medicine of Hiroshima University in central Hiroshima. The title of the seminar was “Business Enterprise by Researchers and Commercial Application of Worm-Based N-NOSE”.
Dr Hirotsu is a CEO of a venture company called HIROTSU Bioscience Co. He founded this company by which to commercialise his discovery on a cancer detection method (N-NOSE) using the worm, Caenorhabditis elegans.

(Photo: Dr Takaaki Hirotsu (left) and President of Hiroshima University Mitsuo Ochi)


18th January 2020
Dr Kin-ichiro (Kinny) Kominami (小南欽一郎) visited the lab and discuss with Takashi the possible commercial exploitation of our research. Kinny was one of the three researchers who went to London in 1994 with Takashi from Japan and work as a research scientist in ICRF (Imperial Cancer Research Fund, currently Francis Crick Institute). Kinny has been working in Nomura and then Mizuho Ltd. for a long time to advise and help researchers start venture companies to commercialise their researches, and recently founded his own company, Tech & FinStrategy Inc., in which he has been acting as President and CEO.

(Lower photo: From the left, Hajime Niwa, Takashi Toda, Kinny Kominami and Dai HIrata in Jul 1994)